{
  "$schema": "http://json-schema.org/draft-07/schema#",
  "$id": "https://schema.humancellatlas.org/module/biomaterial/1.0.0/disease_profile",
  "description": "Information about specific diseases profile of the individual.",
  "additionalProperties": false,
  "title": "Disease profile",
  "name": "disease_profile",
  "type": "object",
  "minProperties": 1,
  "properties": {
    "describedBy": {
      "description": "The URL reference to the schema.",
      "type": "string",
      "pattern": "^(http|https)://schema.(.*?)humancellatlas.org/module/biomaterial/(([0-9]{1,}.[0-9]{1,}.[0-9]{1,})|([a-zA-Z]*?))/disease_profile"
    },
    "schema_version": {
      "description": "The version number of the schema in major.minor.patch format.",
      "type": "string",
      "pattern": "^[0-9]{1,}.[0-9]{1,}.[0-9]{1,}$",
      "example": "0.0.1"
    },
    "copd_gold_stage": {
      "user_friendly": "GOLD stage",
      "description": "Indicate the current GOLD stage (Global Initiative for Chronic Obstructive Lung Disease).",
      "type": "integer",
      "enum": [
        1,
        2,
        3,
        4
      ],
      "example": "1; 2; 3; 4",
      "bionetworks": [
        "lung"
      ],
      "guidelines": "Should be one of 1, 2, 3, 4"
    },
    "copd_mmrc_grade": {
      "user_friendly": "mMRC grade",
      "description": "Indicate the Modified British Medical Research Council (mMRC) dyspnea scale grade.",
      "type": "integer",
      "enum": [
        0,
        1,
        2,
        3,
        4
      ],
      "example": "0, 1; 2; 3; 4",
      "bionetworks": [
        "lung"
      ],
      "guidelines": "Should be one of 0, 1, 2, 3, 4"
    },
    "copd_cat_score": {
      "user_friendly": "CAT score",
      "description": "Indicate the COPD Assessment Test (CAT) score.",
      "type": "integer",
      "minimum": 0,
      "maximum": 40,
      "example": "2; 5; 37",
      "bionetworks": [
        "lung"
      ],
      "guidelines": "Should be between 0 and 40."
    },
    "copd_gold_abe_assessment": {
      "user_friendly": "GOLD ABE assessment",
      "description": "Indicate the Global Initiative for Chronic Obstructive Lung Disease (GOLD) A, B, C, D assessment group if available.",
      "type": "string",
      "enum": [
        "A",
        "B",
        "E"
      ],
      "example": "A; B; E",
      "bionetworks": [
        "lung"
      ],
      "guidelines": "Should be one of A, B, E"
    },
    "copd_phenotype": {
      "user_friendly": "COPD phenotype",
      "description": "Indicate the COPD disease phenotype(s) of donor. Please indicate all applicable phenotypes of donor.",
      "type": "array",
      "items": {
        "type": "string",
        "enum": [
          "COPD not otherwise specified",
          "COPD with emphysema",
          "COPD with bronchitis",
          "COPD with history of asthma",
          "COPD with >300 eos in blood",
          "COPD with allergy",
          "COPD with Chronic Mucus Hypersecretion",
          "COPD with frequent exacerbations"
        ]
      },
      "example": "COPD with bronchitis; COPD with history of asthma; COPD with emphysema",
      "bionetworks": [
        "lung"
      ],
      "guidelines": "Should be one or more of: COPD not otherwise specified, COPD with emphysema, COPD with bronchitis, COPD with history of asthma, COPD with >300 eos in blood, COPD with allergy, COPD with Chronic Mucus Hypersecretion, COPD with frequent exacerbations"
    },
    "copd_emphysema_percentage": {
      "user_friendly": "Percentage of emphysema",
      "description": "Indicate the percentage of the lung that is affected by emphysema as judged based on non-invasive imaging, such as from a CT scan.",
      "type": "number",
      "maximum": 150,
      "minimum": 0,
      "bionetworks": [
        "lung"
      ]
    }
  }
}