{
    "$schema": "http://json-schema.org/draft-07/schema#",
    "description": "Information about how cells are subjected to a treatment or stimulus, such as an immune activator or a drug.",
    "additionalProperties": false,
    "required": [
      "describedBy",
      "schema_type",
      "protocol_core",
      "method"
    ],
    "title": "Treatment protocol",
    "name": "treatment_protocol",
    "type": "object",
    "properties": {
        "describedBy": {
            "description": "The URL reference to the schema.",
            "type": "string",
            "pattern" : "^(http|https)://schema.(.*?)humancellatlas.org/type/protocol/biomaterial_collection/(([0-9]{1,}.[0-9]{1,}.[0-9]{1,})|([a-zA-Z]*?))/treatment_protocol"
        },
        "schema_version": {
            "description": "The version number of the schema in major.minor.patch format.",
            "type": "string",
            "pattern": "^[0-9]{1,}.[0-9]{1,}.[0-9]{1,}$",
            "example": "4.6.1"
        },
        "schema_type": {
            "description": "The type of the metadata schema entity.",
            "type": "string",
            "enum": [
                "protocol"
            ]
        },
        "provenance" : {
            "description": "Provenance information provided by the system.",
            "type": "object",
            "$ref": "system/provenance.json"
        },
        "protocol_core": {
            "description": "Core protocol-level information.",
            "type": "object",
            "$ref": "core/protocol/protocol_core.json",
            "user_friendly": "Protocol core"
        },
        "method": {
            "description": "Method applied to cell culture to induce a specific treatment response.",
            "type": "object",
            "$ref": "module/ontology/treatment_method_ontology.json",
            "user_friendly": "Treatment method",
        },
        "media":{
            "description": "Culture media used to induce a specific treatment response.",
            "type": "string",
            "user_friendly": "Treatment media",
            "example": "RPMI 1640; Complete Medium"
        },
        "reagents": {
            "description": "A list of purchased reagents used in the treatment protocol.",
            "type": "array",
            "items": {
                "type": "object",
                "$ref": "module/process/purchased_reagents.json"
            },
            "user_friendly": "Treatment reagents"
        },
        "target_pathway": {
            "description": "Targeted pathway for specific treatment response.",
            "type": "string",
            "user_friendly": "Target pathway",
            "example": "insulin signalling pathway; immune cell activation; chemokine signalling pathway."
        }
    }
}